STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rcas_4119PFAM: heat shock protein Hsp20; KEGG: rrs:RoseRS_1929 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (149 aa)    
Predicted Functional Partners:
clpB
ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.646
Rcas_1200
PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_4070 ATPase AAA-2 domain protein; Belongs to the ClpA/ClpB family.
  
 
 0.646
Rcas_2016
PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1731 ATPase AAA-2 domain protein; Belongs to the ClpA/ClpB family.
  
 
 0.646
Rcas_4352
ATPase AAA-2 domain protein; PFAM: ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_0187 ATPase AAA-2 domain protein.
  
 
 0.646
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
  
 
 0.606
htpX-2
PFAM: peptidase M48 Ste24p; KEGG: rrs:RoseRS_1928 peptidase M48, Ste24p; Belongs to the peptidase M48B family.
  
  
 0.568
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.557
dnaK-2
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.557
Rcas_4118
PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; KEGG: rrs:RoseRS_1930 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
       0.550
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.546
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.