Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0044Transcriptional regulator, AsnC family; KEGG: pai:PAE0581 heme biosynthesis protein. (332 aa)    
Predicted Functional Partners:
Pisl_0051
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0579 metallo cofactor biosynthesis protein.
  
 0.801
Pisl_0113
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0596 metallo cofactor biosynthesis protein.
  
 0.749
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pai:PAE0594 glutamate-1-semialdehyde aminotransferase (hemL); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
     
 0.577
Pisl_0119
TIGRFAM: siroheme synthase; KEGG: pai:PAE0585 siroheme synthesis protein, conjectural.
 
   
 0.546
Pisl_1332
PFAM: Radical SAM domain protein; KEGG: pai:PAE1252 hypothetical protein.
 
  
 0.493
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
     
 0.467
Pisl_0173
KEGG: afu:AF1615 cofactor modifying protein (cmo).
 
  
 0.430
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
   
 0.414
Pisl_0115
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase.
 
  
 0.409
Pisl_1334
KEGG: pai:PAE1252 hypothetical protein.
 
  
 0.409
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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