Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pisl_0073PFAM: metallophosphoesterase; KEGG: pai:PAE0055 hypothetical protein. (619 aa)    
Predicted Functional Partners:
Pisl_0074
KEGG: pai:PAE0057 hypothetical protein.
       0.890
Pisl_0075
PFAM: extracellular solute-binding protein, family 1; KEGG: pai:PAE0061 extracellular solute binding protein, conjectural.
 
     0.767
Pisl_0028
KEGG: pai:PAE3657 hypothetical protein.
 
     0.619
Pisl_1113
KEGG: pai:PAE0831 hypothetical protein.
  
     0.574
Pisl_0535
PFAM: CBS domain containing protein; KEGG: pai:PAE3169 conserved protein with 7 CBS domains.
 
     0.560
Pisl_0539
PFAM: THUMP domain protein; KEGG: pai:PAE3175 hypothetical protein.
  
     0.555
Pisl_1287
PFAM: ABC-3 protein; KEGG: pai:PAE1247 manganese transport permease protein.
 
     0.528
Pisl_0934
SMART: helicase c2; KEGG: pai:PAE3526 hypothetical protein.
 
     0.522
Pisl_1959
KEGG: pai:PAE0329 putative thiamine transport system permease protein.
 
     0.515
tfe
Transcription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
  
     0.509
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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