Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Pisl_0127PFAM: sodium/calcium exchanger membrane region; KEGG: pai:PAE0566 conserved within P.aerophilum. (326 aa)    
Predicted Functional Partners:
Pisl_0649
Molybdopterin synthase subunit MoaD / molybdopterin synthase subunit MoaE; TIGRFAM: MoaD family protein; PFAM: molybdopterin biosynthesis MoaE; thiamineS protein; KEGG: pai:PAE0727 molybdenum cofactor biosynthesis protein D/E.
  
    0.665
Pisl_0126
HTH DNA binding domain protein; KEGG: pai:PAE0567 hypothetical protein.
       0.651
Pisl_1529
PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: ava:Ava_1011 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
   0.620
Pisl_0716
KEGG: pai:PAE0653 hypothetical protein.
  
     0.553
Pisl_0128
PFAM: periplasmic solute binding protein; KEGG: pai:PAE0564 putative zinc / manganese transport system substrate-binding protein.
       0.519
Pisl_1459
PFAM: glycosyl transferase, group 1; KEGG: pai:PAE0430 glycosyltransferase (type 1).
 
  
 0.517
Pisl_1466
PFAM: glycosyl transferase, group 1; KEGG: pai:PAE0540 glycosyltransferase (type 1).
 
  
 0.450
Pisl_0674
PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin; KEGG: pai:PAE0712 surface layer-associated stable protease, conjectural; Belongs to the peptidase S8 family.
 
    0.438
Pisl_0055
Amino acid/polyamine/organocation transporter, APC superfamily; PFAM: amino acid permease-associated region; KEGG: pai:PAE0556 amino acid permease; TC 2.A.3.
 
 
 0.436
Pisl_1911
Transporter, YbiR family; PFAM: Citrate transporter; KEGG: pai:PAE2457 arsenite transport protein, conjectural.
 
  
 0.434
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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