Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0144PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp; KEGG: pai:PAE2556 glutamine synthetase. (431 aa)    
Predicted Functional Partners:
carA
TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: pai:PAE0946 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family.
 
 
 0.974
carB
TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: pai:PAE0947 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.
  
 0.971
glmS
Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
 
 
 0.960
Pisl_0400
Sulfide dehydrogenase (flavoprotein) subunit SudA; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: pai:PAE3227 glutamate synthase small subunit.
  
 
 0.956
Pisl_0980
Glutamate dehydrogenase (NAD); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE3438 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.948
Pisl_1816
PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE3438 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.948
Pisl_0109
Amidophosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: pai:PAE0218 amidophosphoribosyltransferase (purF).
 
 
 0.935
Pisl_0102
Amidophosphoribosyltransferase; PFAM: glutamine amidotransferase, class-II; KEGG: pai:PAE0226 amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.934
Pisl_1028
2-aminoadipate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: pai:PAE2315 aminotransferase, class I.
    
 0.921
Pisl_1455
PFAM: nitrogen regulatory protein P-II; KEGG: aae:aq_109 nitrogen regulatory PII protein; Belongs to the P(II) protein family.
  
 
 0.918
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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