Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0177PFAM: Nitrate reductase, gamma subunit; KEGG: afu:AF0545 hypothetical protein. (302 aa)    
Predicted Functional Partners:
Pisl_0176
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: afu:AF0543 hypothetical protein.
 
 
 0.955
Pisl_0649
Molybdopterin synthase subunit MoaD / molybdopterin synthase subunit MoaE; TIGRFAM: MoaD family protein; PFAM: molybdopterin biosynthesis MoaE; thiamineS protein; KEGG: pai:PAE0727 molybdenum cofactor biosynthesis protein D/E.
  
  
 0.806
Pisl_1962
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE1331 conserved iron-sulfur protein.
 
 
 0.748
Pisl_0174
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE1331 conserved iron-sulfur protein.
 
 
 0.724
Pisl_0171
KEGG: pai:PAE2572 sulfite reductase alpha subunit; TIGRFAM: sulfite reductase, dissimilatory-type alpha subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region.
 
   
 0.715
Pisl_0170
KEGG: pai:PAE2571 sulfite reductase beta subunit; TIGRFAM: sulfite reductase, dissimilatory-type beta subunit; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region.
 
   
 0.709
Pisl_0179
PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE2573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
    0.704
Pisl_0168
PFAM: DsrC family protein; KEGG: pai:PAE2566 siroheme-sulfite reductase gamma subunit homolog.
 
   
 0.665
cbiA
Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
   
 0.661
Pisl_0198
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: afu:AF0547 reductase, iron-sulfur binding subunit.
 
 
 0.623
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.