Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0179PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE2573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (222 aa)    
Predicted Functional Partners:
Pisl_0119
TIGRFAM: siroheme synthase; KEGG: pai:PAE0585 siroheme synthesis protein, conjectural.
 
 
 0.981
Pisl_0116
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase.
  
 
 0.930
cbiA
Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.923
Pisl_0115
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase.
  
  
 
0.916
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
  
 0.809
Pisl_1809
Phosphoadenosine phosphosulfate reductase; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; phosphoadenosine phosphosulfate reductase; KEGG: pai:PAE1989 hypothetical protein.
 
  
 0.809
cysC
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.759
Pisl_1511
KEGG: pai:PAE2609 sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase.
  
  
 0.758
Pisl_0177
PFAM: Nitrate reductase, gamma subunit; KEGG: afu:AF0545 hypothetical protein.
  
    0.704
Pisl_0649
Molybdopterin synthase subunit MoaD / molybdopterin synthase subunit MoaE; TIGRFAM: MoaD family protein; PFAM: molybdopterin biosynthesis MoaE; thiamineS protein; KEGG: pai:PAE0727 molybdenum cofactor biosynthesis protein D/E.
  
  
 0.613
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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