Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
Pisl_0197PFAM: nickel-dependent hydrogenase, large subunit; KEGG: sma:SAV7367 putative cytochrome C3-like hydrogenase (NiFeSe) large chain. (638 aa)    
Predicted Functional Partners:
Pisl_0200
PFAM: Nickel-iron dehydrogenase small subunit, N-terminal domain protein; KEGG: fal:FRAAL2392 uptake hydrogenase small subunit precursor (hydrogenlyase) (membrane-bound hydrogenase small subunit).
 
 0.999
Pisl_0196
TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein; KEGG: aeh:Mlg_2026 hydrogenase expression/formation protein.
 
 
 0.981
Pisl_0192
PFAM: hydrogenase expression/synthesis, HypA; KEGG: sto:ST1046 hypothetical protein.
 
 
 0.970
Pisl_0205
PFAM: hydrogenase formation HypD protein; KEGG: tko:TK2000 hydrogenase expression/formation protein HypD.
 
 
 0.921
Pisl_0170
KEGG: pai:PAE2571 sulfite reductase beta subunit; TIGRFAM: sulfite reductase, dissimilatory-type beta subunit; PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region.
     
 0.907
Pisl_0171
KEGG: pai:PAE2572 sulfite reductase alpha subunit; TIGRFAM: sulfite reductase, dissimilatory-type alpha subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region.
     
 0.907
Pisl_0207
TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: acylphosphatase; SUA5/yciO/yrdC, N-terminal domain; zinc finger, HypF domain protein; KEGG: pab:PAB1560 hydrogenase expression/formation regulatory protein.
 
 
 
 0.897
Pisl_0203
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mth:MTH205 hydrogenase expression/formation protein HypE.
 
   
 0.847
Pisl_0193
Transcriptional regulator, CopG family; KEGG: pab:PAB0960 putative nickel responsive regulator.
     
 0.809
Pisl_0194
Hypothetical protein.
       0.785
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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