Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0198PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: afu:AF0547 reductase, iron-sulfur binding subunit. (431 aa)    
Predicted Functional Partners:
Pisl_0200
PFAM: Nickel-iron dehydrogenase small subunit, N-terminal domain protein; KEGG: fal:FRAAL2392 uptake hydrogenase small subunit precursor (hydrogenlyase) (membrane-bound hydrogenase small subunit).
 
   
 0.789
Pisl_0197
PFAM: nickel-dependent hydrogenase, large subunit; KEGG: sma:SAV7367 putative cytochrome C3-like hydrogenase (NiFeSe) large chain.
 
 
 
 0.776
Pisl_0196
TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein; KEGG: aeh:Mlg_2026 hydrogenase expression/formation protein.
 
   
 0.707
Pisl_0199
Hypothetical protein.
     
 0.661
Pisl_0202
Hypothetical protein.
       0.627
Pisl_0177
PFAM: Nitrate reductase, gamma subunit; KEGG: afu:AF0545 hypothetical protein.
 
 
 0.623
Pisl_0201
Hypothetical protein.
       0.620
Pisl_1342
PFAM: protein of unknown function DUF162; KEGG: pai:PAE1289 hypothetical protein.
  
 
 0.617
Pisl_1348
PFAM: protein of unknown function DUF162; KEGG: pai:PAE1289 hypothetical protein.
  
 
 0.617
Pisl_0193
Transcriptional regulator, CopG family; KEGG: pab:PAB0960 putative nickel responsive regulator.
       0.600
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.