Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pisl_0218PFAM: AMP-dependent synthetase and ligase; KEGG: pai:PAE2867 acetyl-coenzyme A synthetase. (572 aa)    
Predicted Functional Partners:
Pisl_1692
KEGG: pai:PAE1689 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 0.950
Pisl_1343
PFAM: malate synthase; KEGG: pai:PAE1287 malate synthase.
  
 0.945
Pisl_0813
KEGG: pai:PAE2183 acetyl-CoA C-acyltransferase.
  
 
 0.932
Pisl_1301
KEGG: pai:PAE1220 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase.
  
 
 0.932
Pisl_1437
PFAM: Thiolase; KEGG: pai:PAE1377 acetyl-CoA C-acyltransferase.
  
 
 0.932
Pisl_0485
acetyl-CoA synthetase (ADP-forming) beta subunit; KEGG: pai:PAE3249 hypothetical protein.
    
 0.920
Pisl_1355
TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase.
  
 
 0.919
Pisl_1808
TIGRFAM: homocitrate synthase; PFAM: regulatory protein, AsnC/Lrp family; pyruvate carboxyltransferase; KEGG: pai:PAE1986 2-isopropylmalate synthase.
  
 
 0.919
Pisl_1814
2-isopropylmalate synthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; PFAM: pyruvate carboxyltransferase; KEGG: pai:PAE1993 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.919
Pisl_1175
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pai:PAE0939 2-oxoacid ferredoxin oxidoreductase alpha subunit.
  
 
 0.916
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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