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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Pisl_0225TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM domain protein; KEGG: neq:NEQ381 conserved hypothetical protein containing radical SAM domain. (239 aa)    
Predicted Functional Partners:
Pisl_0226
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tko:TK2298 anaerobic ribonucleoside-triphosphate reductase.
 
  
 0.976
Pisl_0224
Hypothetical protein.
       0.685
Pisl_1601
PFAM: iron-containing alcohol dehydrogenase; KEGG: mta:Moth_1911 iron-containing alcohol dehydrogenase.
 
  
 0.668
Pisl_0227
PFAM: periplasmic binding protein; KEGG: fnu:FN0305 iron(III) dicitrate-binding protein.
  
    0.543
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.522
Pisl_0229
Protoporphyrin IX magnesium-chelatase; KEGG: mhu:Mhun_0291 magnesium chelatase, ChlI subunit; PFAM: magnesium chelatase, ChlI subunit; von Willebrand factor, type A; SMART: AAA ATPase.
       0.500
Pisl_0228
Cobaltochelatase CobN subunit; PFAM: CobN/magnesium chelatase; KEGG: gvi:glr3328 magnesium protoporphyrin IX chelatase subunit H.
       0.497
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
  
 0.449
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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