Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0271PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: pai:PAE2868 homoserine dehydrogenase. (303 aa)    
Predicted Functional Partners:
Pisl_0272
KEGG: pai:PAE2876 aspartate-semialdehyde dehydrogenase (asd); TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region.
 
 0.998
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.997
Pisl_0273
PFAM: aspartate/glutamate/uridylate kinase; KEGG: pai:PAE2877 aspartate kinase.
 
 0.994
Pisl_0274
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.986
Pisl_0881
Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: pai:PAE2420 cystathionine gamma-synthase.
 
 
 0.950
dapAL
PFAM: dihydrodipicolinate synthetase; KEGG: pai:PAE2915 dihydrodipicolinate synthase; Belongs to the DapA family.
  
 
 0.947
Pisl_0030
PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: pai:PAE3655 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase.
 
 
 0.921
Pisl_1761
Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: pfu:PF1858 cysteine synthase.
 
 
 0.883
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.835
lysZ
N-acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily.
 
  
 0.775
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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