Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pisl_0299KEGG: pai:PAE2902 hypothetical protein. (423 aa)    
Predicted Functional Partners:
Pisl_0300
PFAM: protein of unknown function DUF87; KEGG: pai:PAE2903 hypothetical protein.
   
 
 0.970
Pisl_0302
PFAM: SMC domain protein; KEGG: pai:PAE2905 purine NTPase, probable.
     
 0.886
Pisl_0395
PFAM: protein of unknown function DUF87; KEGG: pai:PAE2998 hypothetical protein.
   
 
 0.860
Pisl_0301
PFAM: metallophosphoesterase; KEGG: pai:PAE2904 exonuclease SbcD, conjectural.
       0.850
Pisl_0145
SMART: AAA ATPase; KEGG: pai:PAE3527 hypothetical protein.
   
 
 0.767
Pisl_0941
SMART: AAA ATPase; KEGG: pai:PAE2155 conserved within P.aerophilum.
   
 
 0.767
Pisl_0829
PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1; KEGG: pai:PAE2197 predicted phosphoesterase.
   
    0.529
Pisl_0884
PFAM: SMC domain protein; KEGG: pai:PAE2280 hypothetical protein.
     
 0.514
hjc
Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
     
 0.466
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
     
 0.460
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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