Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0301PFAM: metallophosphoesterase; KEGG: pai:PAE2904 exonuclease SbcD, conjectural. (386 aa)    
Predicted Functional Partners:
Pisl_0302
PFAM: SMC domain protein; KEGG: pai:PAE2905 purine NTPase, probable.
 
 0.999
Pisl_0884
PFAM: SMC domain protein; KEGG: pai:PAE2280 hypothetical protein.
 
 0.993
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
 0.966
Pisl_0486
Rad51-like protein; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
 
 0.930
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
 
 0.929
Pisl_0300
PFAM: protein of unknown function DUF87; KEGG: pai:PAE2903 hypothetical protein.
 
   
 0.921
Pisl_0934
SMART: helicase c2; KEGG: pai:PAE3526 hypothetical protein.
 
 0.877
Pisl_0299
KEGG: pai:PAE2902 hypothetical protein.
       0.850
Pisl_0390
PFAM: DEAD_2 domain protein; SMART: DEXDc2; helicase c2; KEGG: pai:PAE2991 hypothetical protein.
  
 0.845
top6A
Spo11/DNA topoisomerase VI, subunit A, N-terminal domain protein; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
   
 0.836
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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