Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0489PFAM: aldo/keto reductase; KEGG: pai:PAE3247 morphine 6-dehydrogenase, conjectural. (277 aa)    
Predicted Functional Partners:
Pisl_0488
PFAM: GCN5-related N-acetyltransferase; KEGG: pai:PAE3246 hypothetical protein.
  
    0.792
Pisl_1949
PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ape:APE1245 alcohol dehydrogenase.
 
 
 0.679
Pisl_0249
Succinate-semialdehyde dehydrogenase (NAD(P)(+)); PFAM: aldehyde dehydrogenase; KEGG: sto:ST0064 glyceraldehyde-3-phosphate dehydrogenase, NADP dependent.
 
 
 0.598
Pisl_0486
Rad51-like protein; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
  
  
 0.568
Pisl_0487
Hypothetical protein; KEGG: pai:PAE3245 conserved within P.aerophilum.
       0.561
Pisl_0413
PFAM: isochorismatase hydrolase; KEGG: pai:PAE3001 isochorismatase, putative.
 
    0.515
Pisl_1688
KEGG: pai:PAE1683 hypothetical protein.
  
  
 0.511
Pisl_1089
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pai:PAE0797 short chain dehydrogenase.
 
 
 0.510
Pisl_0342
KEGG: pai:PAE2936 hypothetical protein.
 
 
 0.489
Pisl_2010
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
 
 0.483
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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