Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pisl_0508KEGG: pai:PAE3262 hypothetical protein. (136 aa)    
Predicted Functional Partners:
Pisl_0509
PFAM: protein of unknown function DUF814; KEGG: pai:PAE3259 hypothetical protein.
       0.806
Pisl_1658
PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 conserved hypothetical protein; Belongs to the UPF0201 family.
  
     0.556
Pisl_0510
Endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease, family 2; KEGG: pai:PAE3257 DNA-(apurinic or apyrimidinic site) lyase (endonuclease IV).
       0.555
Pisl_0347
KEGG: pai:PAE2941 hypothetical protein.
 
     0.552
Pisl_0616
PFAM: CBS domain containing protein; KEGG: pai:PAE2364 conserved protein with 4 CBS domains.
       0.537
Pisl_0564
PFAM: PfkB domain protein; KEGG: pai:PAE3318 kinase, conjectural.
 
     0.536
pelA
Cell division protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
 
     0.497
Pisl_0614
TIGRFAM: Glutaredoxin-like domain protein; PFAM: Thioredoxin domain; KEGG: pai:PAE2366 glutaredoxin-like protein.
       0.471
Pisl_0341
PFAM: THUMP domain protein; KEGG: pai:PAE2935 hypothetical protein.
  
     0.445
Pisl_0539
PFAM: THUMP domain protein; KEGG: pai:PAE3175 hypothetical protein.
  
     0.444
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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