Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa)    
Predicted Functional Partners:
Pisl_0386
PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; KEGG: pai:PAE2986 GTP cyclohydrolase II.
 
 
 0.999
Pisl_1833
TIGRFAM: riboflavin synthase; KEGG: pai:PAE2021 riboflavin synthase beta chain.
 
  
  0.971
Pisl_0385
2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; KEGG: pai:PAE2985 riboflavin specific deaminase, putative; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein.
 
 
 0.954
pyrB
KEGG: pai:PAE0770 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
  
    0.813
rpl13
LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
    0.789
Pisl_0687
FMN adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase; KEGG: pai:PAE0683 cytidyltransferase.
 
   
 0.754
Pisl_0343
KEGG: pai:PAE2937 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS.
  
  
 0.728
Pisl_0507
PFAM: dihydroorotate dehydrogenase; KEGG: pai:PAE3263 dihydroorotate dehydrogenase.
  
  
 0.717
rpl6
LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
    0.691
rps12
SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.
   
    0.684
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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