Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_05712'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (187 aa)    
Predicted Functional Partners:
cca
tRNA adenylyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
 
   
 0.927
Pisl_0572
Transcriptional regulator, MarR family; PFAM: regulatory protein, MarR; KEGG: pai:PAE3327 DNA binding transcriptional repressor, conjectural.
       0.895
Pisl_0569
KEGG: pai:PAE3324 hypothetical protein.
       0.758
Pisl_0574
snoRNP protein GAR1; KEGG: pai:PAE3330 hypothetical protein; involved in rRNA processing.
     
 0.696
Pisl_0573
PFAM: Zinc finger, TFIIB-type domain protein; Transcription factor TFIIB, cyclin-related; SMART: Cyclin; KEGG: pai:PAE3329 transcription initiation factor IIB (TFIIB).
       0.677
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
       0.650
Pisl_1653
KEGG: pai:PAE1625 putative serine/threonine protein kinase.
       0.567
Pisl_1657
KEGG: pai:PAE1629 adenylate kinase, conjectural.
       0.557
Pisl_1658
PFAM: Protein of unknown function DUF54; KEGG: pai:PAE1632 conserved hypothetical protein; Belongs to the UPF0201 family.
       0.557
Pisl_1152
Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family.
      
 0.445
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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