Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0636PFAM: nitroreductase; KEGG: pai:PAE2336 hypothetical protein. (237 aa)    
Predicted Functional Partners:
Pisl_2013
PFAM: ABC-2 type transporter; KEGG: pai:PAE0270 membrane protein.
 
  
 0.715
Pisl_0902
PFAM: ABC-2 type transporter; KEGG: pai:PAE3065 ABC-2 type transport system, membrane protein.
  
  
 0.671
Pisl_1969
PFAM: ABC-2 type transporter; KEGG: pai:PAE0316 ABC-2 type transport system, membrane protein.
  
  
 0.671
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.640
Pisl_0638
PFAM: AMP-dependent synthetase and ligase; KEGG: pai:PAE2333 medium-chain acyl-CoA ligase.
   
 
 0.602
Pisl_1435
PFAM: AMP-dependent synthetase and ligase; KEGG: pai:PAE1379 long-chain-fatty-acid--CoA ligase.
   
 
 0.602
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.581
Pisl_1134
PFAM: Abortive infection protein; KEGG: pai:PAE0872 hypothetical protein.
 
  
 0.552
Pisl_0634
PFAM: Methyltransferase type 11; KEGG: pai:PAE2338 ubiquinone/menaquinone biosynthesis methyltransferase (ubiE), conjectural.
       0.547
Pisl_0635
KEGG: pai:PAE2337 hypothetical protein.
       0.547
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.