Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (118 aa)    
Predicted Functional Partners:
Pisl_0676
KEGG: pai:PAE0708 hypothetical protein.
       0.738
ef1b
Translation elongation factor 1B (aEF-1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
 
    0.674
Pisl_0103
PFAM: formyl transferase domain protein; KEGG: pai:PAE0219 phosphoribosylglycinamide formyltransferase.
  
   0.671
truD
Pseudouridylate synthase; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
    0.648
infB
Translation initiation factor eaIF-5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
 
  
 0.642
Pisl_1900
PFAM: ornithine cyclodeaminase/mu-crystallin; KEGG: pai:PAE2445 ornithine cyclodeaminase (ArcB).
 
 
   0.634
Pisl_1313
TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein; KEGG: pai:PAE1204 pantothenate metabolism flavoprotein (dfp).
   
 
 0.625
Pisl_0674
PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin; KEGG: pai:PAE0712 surface layer-associated stable protease, conjectural; Belongs to the peptidase S8 family.
 
     0.615
Pisl_0685
PFAM: Protein of unknown function DUF1610; KEGG: pai:PAE0694 hypothetical protein.
       0.565
eif6
Translation initiation factor 6 (aeIF-6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
 
    0.533
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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