Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (221 aa)    
Predicted Functional Partners:
Pisl_0687
FMN adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase; KEGG: pai:PAE0683 cytidyltransferase.
 
     0.930
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
     
 0.675
psmB1
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.567
Pisl_1603
PFAM: Dual specificity protein phosphatase; KEGG: pai:PAE1536 conserved protein (possible dual specificity phosphatase).
     
 0.559
Pisl_0688
KEGG: pai:PAE0681 conserved hypothetical protein; Belongs to the UPF0179 family.
       0.486
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
     
 0.470
pcn-2
Proliferating-cell nuclear antigen-like protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
     
 0.470
nucS
Protein of unknown function DUF91; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
      
 0.458
hel308
DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
      
 0.449
Pisl_0685
PFAM: Protein of unknown function DUF1610; KEGG: pai:PAE0694 hypothetical protein.
       0.442
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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