Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0690PFAM: Protein of unknown function DUF460; KEGG: pai:PAE0678 hypothetical protein. (591 aa)    
Predicted Functional Partners:
Pisl_0689
PFAM: protein of unknown function RIO1; KEGG: pai:PAE0680 RIO-like serine/threonine protein kinase.
 
     0.913
Pisl_0688
KEGG: pai:PAE0681 conserved hypothetical protein; Belongs to the UPF0179 family.
 
     0.747
Pisl_1073
PFAM: protein of unknown function DUF75; KEGG: pai:PAE0779 hypothetical protein.
  
     0.658
Pisl_1114
TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: pai:PAE0832 adenylate cyclase.
  
     0.556
Pisl_1831
Phosphate uptake regulator, PhoU; PFAM: SpoVT/AbrB domain protein; PhoU family protein; KEGG: pai:PAE2019 hypothetical protein.
  
     0.552
Pisl_0768
PFAM: Radical SAM domain protein; KEGG: pai:PAE2255 hypothetical protein.
  
     0.540
Pisl_1314
KEGG: pai:PAE1205 hypothetical protein.
  
     0.513
Pisl_1674
NMD3; PFAM: NMD3; KEGG: pai:PAE1653 hypothetical protein.
  
     0.511
nusA
NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.
 
     0.494
tfe
Transcription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
  
     0.456
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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