Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0709PFAM: zinc finger, C2H2-type domain protein; KEGG: pai:PAE0659 hypothetical protein containing 3 C2H2 zinc finger motifs. (104 aa)    
Predicted Functional Partners:
carS
Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
       0.917
Pisl_0707
PFAM: Vacuolar H+-transporting two-sector ATPase, F subunit; KEGG: pai:PAE0661 H+-transporting ATP synthase subunit F (atpF).
       0.739
Pisl_1568
KEGG: pai:PAE1451 hypothetical protein.
  
     0.635
atpE
H+-transporting two-sector ATPase, E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
       0.616
atpA
Sodium-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.
       0.614
Pisl_0710
KEGG: pai:PAE0658 hypothetical protein.
       0.594
Pisl_0786
PFAM: Miro domain protein; KEGG: pai:PAE3492 conserved within P.aerophilum.
  
     0.575
rpoH
DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
       0.541
Pisl_0703
DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
     0.514
rpl30e
PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: pai:PAE0668 ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family.
 
     0.494
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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