Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0728Transcriptional regulator, Fis family; PFAM: peptidase M24; KEGG: pai:PAE0637 peptidase (possible proline dipeptidase); Belongs to the peptidase M24B family. (346 aa)    
Predicted Functional Partners:
Pisl_0727
PFAM: protein of unknown function DUF437; KEGG: pai:PAE0638 hypothetical protein.
       0.710
Pisl_1592
PFAM: Amidase; KEGG: pai:PAE1525 Glu-tRNA(Gln) amidotransferase subunit A.
   
 
 0.596
map
Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
 
  
 0.595
Pisl_0725
PFAM: iron dependent repressor; transcriptional regulator TrmB; KEGG: pai:PAE0640 hypothetical protein.
       0.523
Pisl_0726
KEGG: pai:PAE0639 hypothetical protein.
       0.523
Pisl_0380
KEGG: pai:PAE2980 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family.
 
   
 0.461
Pisl_1642
PFAM: HEAT domain containing protein; peptidase M1, membrane alanine aminopeptidase; PBS lyase HEAT domain protein repeat-containing protein; KEGG: pai:PAE1597 aminopeptidase.
  
 
 0.432
Pisl_1645
TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: sugar isomerase (SIS); KEGG: pai:PAE1610 hypothetical protein.
 
  
 0.431
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
 
 
 
 0.405
Pisl_0637
TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: pai:PAE2335 possible succinyl-diaminopimelate desuccinylase.
 
 
 0.401
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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