Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0729KEGG: pai:PAE0636 hypothetical protein. (278 aa)    
Predicted Functional Partners:
Pisl_0539
PFAM: THUMP domain protein; KEGG: pai:PAE3175 hypothetical protein.
  
     0.596
Pisl_0730
KEGG: pai:PAE0635 hypothetical protein.
       0.572
Pisl_1287
PFAM: ABC-3 protein; KEGG: pai:PAE1247 manganese transport permease protein.
       0.532
Pisl_1834
Transcriptional regulator, CopG family; PFAM: CopG domain protein DNA-binding domain protein; KEGG: pai:PAE2022 conserved (helix-turn-helix protein, CopG family).
       0.532
Pisl_0842
PFAM: Protein of unknown function DUF54; KEGG: pai:PAE2213 hypothetical protein.
  
     0.478
Pisl_0128
PFAM: periplasmic solute binding protein; KEGG: pai:PAE0564 putative zinc / manganese transport system substrate-binding protein.
       0.436
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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