Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0739PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0616 metallo cofactor biosynthesis protein. (347 aa)    
Predicted Functional Partners:
ilvD
KEGG: pai:PAE0615 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
       0.714
Pisl_0961
KEGG: pai:PAE2109 DNA-directed DNA polymerase (B3); TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B.
   
    0.662
Pisl_0736
PFAM: PilT protein domain protein; SMART: Nucleotide binding protein, PINc; KEGG: pai:PAE0626 hypothetical protein.
  
    0.569
Pisl_0738
PFAM: aldehyde ferredoxin oxidoreductase; Aldehyde ferredoxin oxidoreductase-like; KEGG: pai:PAE0622 aldehyde ferredoxin oxidoreductase.
       0.517
Pisl_0816
PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: pai:PAE2180 DNA-directed DNA polymerase (B1).
   
    0.505
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
     0.462
Pisl_0802
PFAM: metallophosphoesterase; KEGG: pai:PAE2243 hypothetical protein.
     
 0.449
Pisl_0913
TIGRFAM: LPXTG-motif cell wall anchor domain; KEGG: pai:PAE3088 oligopeptide binding protein, putative.
     
 0.449
Pisl_0716
KEGG: pai:PAE0653 hypothetical protein.
      
 0.438
Pisl_0718
TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily; KEGG: pai:PAE0651 uracil DNA glycosylase (Pa-UDGa).
      
 0.438
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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