node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pisl_0554 | Pisl_1029 | Pisl_0554 | Pisl_1029 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | 0.973 |
Pisl_0554 | Pisl_1355 | Pisl_0554 | Pisl_1355 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | 0.914 |
Pisl_0554 | Pisl_1808 | Pisl_0554 | Pisl_1808 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | TIGRFAM: homocitrate synthase; PFAM: regulatory protein, AsnC/Lrp family; pyruvate carboxyltransferase; KEGG: pai:PAE1986 2-isopropylmalate synthase. | 0.925 |
Pisl_0554 | Pisl_1814 | Pisl_0554 | Pisl_1814 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | 2-isopropylmalate synthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; PFAM: pyruvate carboxyltransferase; KEGG: pai:PAE1993 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.914 |
Pisl_0554 | Pisl_1815 | Pisl_0554 | Pisl_1815 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pai:PAE1995 3-isopropylmalate dehydrogenase. | 0.980 |
Pisl_0554 | ilvC | Pisl_0554 | Pisl_0552 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
Pisl_0554 | ilvD | Pisl_0554 | Pisl_0740 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | KEGG: pai:PAE0615 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.993 |
Pisl_0554 | leuC | Pisl_0554 | Pisl_1806 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.804 |
Pisl_0554 | leuD | Pisl_0554 | Pisl_1813 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.856 |
Pisl_1029 | Pisl_0554 | Pisl_1029 | Pisl_0554 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | 0.973 |
Pisl_1029 | Pisl_1815 | Pisl_1029 | Pisl_1815 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pai:PAE1995 3-isopropylmalate dehydrogenase. | 0.962 |
Pisl_1029 | ilvC | Pisl_1029 | Pisl_0552 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.838 |
Pisl_1029 | ilvD | Pisl_1029 | Pisl_0740 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | KEGG: pai:PAE0615 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.933 |
Pisl_1029 | leuC | Pisl_1029 | Pisl_1806 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.675 |
Pisl_1029 | leuD | Pisl_1029 | Pisl_1813 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: pai:PAE2316 threonine dehydratase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.726 |
Pisl_1355 | Pisl_0554 | Pisl_1355 | Pisl_0554 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: pai:PAE3300 acetolactate synthase large subunit. | 0.914 |
Pisl_1355 | Pisl_1808 | Pisl_1355 | Pisl_1808 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | TIGRFAM: homocitrate synthase; PFAM: regulatory protein, AsnC/Lrp family; pyruvate carboxyltransferase; KEGG: pai:PAE1986 2-isopropylmalate synthase. | 0.916 |
Pisl_1355 | Pisl_1814 | Pisl_1355 | Pisl_1814 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | 2-isopropylmalate synthase; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; PFAM: pyruvate carboxyltransferase; KEGG: pai:PAE1993 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.912 |
Pisl_1355 | Pisl_1815 | Pisl_1355 | Pisl_1815 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pai:PAE1995 3-isopropylmalate dehydrogenase. | 0.879 |
Pisl_1355 | ilvC | Pisl_1355 | Pisl_0552 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: pai:PAE1330 2-isopropylmalate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.863 |