Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0744PFAM: proteinase inhibitor I4, serpin; KEGG: pai:PAE0049 serine protease inhibitor (serpin); Belongs to the serpin family. (380 aa)    
Predicted Functional Partners:
Pisl_1642
PFAM: HEAT domain containing protein; peptidase M1, membrane alanine aminopeptidase; PBS lyase HEAT domain protein repeat-containing protein; KEGG: pai:PAE1597 aminopeptidase.
 
 
 0.722
Pisl_1102
PFAM: protein kinase; SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: pai:PAE0815 serine/threonine protein kinase, putative.
  
 
 0.453
Pisl_0055
Amino acid/polyamine/organocation transporter, APC superfamily; PFAM: amino acid permease-associated region; KEGG: pai:PAE0556 amino acid permease; TC 2.A.3.
  
 
 0.428
Pisl_0743
PFAM: protein of unknown function DUF1130; KEGG: pai:PAE0614 hypothetical protein.
       0.403
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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