Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0791KEGG: pai:PAE3498 hypothetical protein. (242 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.645
Pisl_0245
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: pai:PAE2371 NADH oxidase (nox).
   
 0.603
Pisl_0611
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: pai:PAE2371 NADH oxidase (nox).
   
 0.603
Pisl_0790
KEGG: pai:PAE3497 hypothetical protein.
       0.586
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.542
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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