Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0849KEGG: pai:PAE2242 hypothetical protein. (431 aa)    
Predicted Functional Partners:
Pisl_0558
PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: pai:PAE3309 putative mRNA 3-end processing factor.
   
 0.834
Pisl_0973
KEGG: pai:PAE3418 putative mRNA 3-end processing factor.
   
 0.834
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
    
 0.739
Pisl_1079
KEGG: pai:PAE0789 hypothetical protein.
    
 0.739
Pisl_1824
Bis(5'nucleosyl)-tetraphosphatase, ApaH; PFAM: metallophosphoesterase; SMART: serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase; KEGG: pai:PAE2004 serine/threonine specific protein phosphatase.
  
  
 0.643
priL
DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
 
     0.584
Pisl_0850
PFAM: magnesium chelatase, ChlI subunit; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE2240 hypothetical protein.
       0.575
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
  
 0.567
Pisl_0851
PFAM: von Willebrand factor, type A; KEGG: pai:PAE2239 hypothetical protein.
       0.564
rpl40e
PFAM: Ribosomal protein L40e; KEGG: pai:PAE3255 ribosomal protein L40; Belongs to the eukaryotic ribosomal protein eL40 family.
     
  0.559
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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