Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0860Phosphate uptake regulator, PhoU; PFAM: SpoVT/AbrB domain protein; PhoU family protein; KEGG: pai:PAE2220 hypothetical protein. (339 aa)    
Predicted Functional Partners:
pstB
Phosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
 
  
 0.860
Pisl_1526
PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pai:PAE1395 phosphate ABC transporter, permease protein; TC 3.A.1.7.1.
 
  
 0.774
Pisl_0258
KEGG: pai:PAE1395 phosphate ABC transporter, permease protein; TC 3.A.1.7.1.
  
  
 0.743
ribK
CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
  
     0.649
Pisl_1337
Protein of unknown function DUF650; Involved in DNA damage repair.
 
     0.618
dtdA
Protein of unknown function DUF516; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
 
     0.592
Pisl_1187
PFAM: protein of unknown function DUF99; KEGG: pai:PAE0952 conserved hypothetical protein; Belongs to the UPF0215 family.
 
     0.578
priL
DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
     0.568
Pisl_1660
PFAM: Protein of unknown function DUF373; KEGG: pai:PAE1635 hypothetical protein.
  
     0.554
Pisl_2015
TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24, S26A and S26B; KEGG: pai:PAE0264 signal peptidase.
 
    0.545
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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