Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0889PFAM: nitroreductase; KEGG: pai:PAE2273 reductase, putative. (238 aa)    
Predicted Functional Partners:
Pisl_0888
KEGG: pai:PAE2275 hypothetical protein.
       0.689
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
   
 0.687
Pisl_0902
PFAM: ABC-2 type transporter; KEGG: pai:PAE3065 ABC-2 type transport system, membrane protein.
  
  
 0.671
Pisl_1969
PFAM: ABC-2 type transporter; KEGG: pai:PAE0316 ABC-2 type transport system, membrane protein.
  
  
 0.671
Pisl_2013
PFAM: ABC-2 type transporter; KEGG: pai:PAE0270 membrane protein.
  
  
 0.671
Pisl_0887
SMART: actin/actin family protein; KEGG: pai:PAE2276 hypothetical protein.
       0.625
Pisl_0886
KEGG: pai:PAE2278 actin-like protein.
       0.623
Pisl_0884
PFAM: SMC domain protein; KEGG: pai:PAE2280 hypothetical protein.
       0.622
Pisl_0885
Hypothetical protein.
       0.614
Pisl_0638
PFAM: AMP-dependent synthetase and ligase; KEGG: pai:PAE2333 medium-chain acyl-CoA ligase.
   
 
 0.602
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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