Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pisl_0905PFAM: protein of unknown function DUF72; KEGG: pai:PAE3079 hypothetical protein. (239 aa)    
Predicted Functional Partners:
Pisl_0906
KEGG: pai:PAE3080 hypothetical protein.
       0.588
Pisl_0021
Predicted hydrolase of the metallo-beta-lactamase superfamily; KEGG: pai:PAE3680 hypothetical protein; Belongs to the UPF0282 family.
 
     0.520
Pisl_1861
PFAM: Protein of unknown function DUF429; KEGG: pai:PAE2091 hypothetical protein.
  
     0.514
Pisl_0907
KEGG: pai:PAE3081 hypothetical protein.
       0.498
Pisl_0564
PFAM: PfkB domain protein; KEGG: pai:PAE3318 kinase, conjectural.
 
     0.460
Pisl_0548
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
 
     0.459
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.436
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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