Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0908Asparaginase; PFAM: peptidase T2, asparaginase 2; KEGG: pai:PAE3083 asparaginase. (299 aa)    
Predicted Functional Partners:
Pisl_1452
Aspartate-ammonia ligase; PFAM: asparagine synthase; KEGG: pai:PAE0376 asparagine synthetase.
  
  
 0.928
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
  0.919
Pisl_0770
PFAM: aminotransferase, class I and II; KEGG: pai:PAE2251 aspartate aminotransferase (aspC), conjectural.
    
 0.906
Pisl_1791
L-aspartate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: pai:PAE1964 aspartate aminotransferase, conjectural.
    
 0.906
pyrB
KEGG: pai:PAE0770 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
    
  0.902
pyrI
Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
  0.901
Pisl_0279
PFAM: argininosuccinate synthase; KEGG: pai:PAE2884 argininosuccinate synthase.
     
 0.900
Pisl_0273
PFAM: aspartate/glutamate/uridylate kinase; KEGG: pai:PAE2877 aspartate kinase.
    
 0.833
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
     
  0.800
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
       0.797
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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