Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Pisl_0933KEGG: pai:PAE3546 hypothetical protein. (123 aa)    
Predicted Functional Partners:
Pisl_0932
PFAM: peptidase M48, Ste24p; KEGG: pai:PAE3547 heat shock protein, HtpX homolog, conjectural.
       0.696
Pisl_0931
KEGG: pai:PAE3548 hypothetical protein.
       0.686
Pisl_0934
SMART: helicase c2; KEGG: pai:PAE3526 hypothetical protein.
       0.426
Pisl_0935
KEGG: pai:PAE3524 hypothetical protein.
       0.414
surE-2
5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
       0.403
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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