Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0944PFAM: protein of unknown function DUF711; KEGG: pai:PAE2151 hypothetical protein. (321 aa)    
Predicted Functional Partners:
Pisl_0945
SMART: iron-sulfur cluster loop; KEGG: pai:PAE2138 hypothetical protein.
       0.888
Pisl_0758
PFAM: amino acid-binding ACT domain protein; KEGG: pai:PAE3582 ACT domain-containing protein; Belongs to the UPF0237 family.
 
     0.784
Pisl_0943
PFAM: protein of unknown function DUF437; KEGG: pai:PAE2152 hypothetical protein.
       0.640
Pisl_0946
KEGG: pai:PAE2137 hypothetical protein.
       0.574
Pisl_0947
Molybdopterin synthase subunit MoaD; TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pai:PAE2135 hypothetical protein.
       0.507
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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