Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0946KEGG: pai:PAE2137 hypothetical protein. (126 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
 0.954
queC
ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
  
  
 0.950
Pisl_1968
PFAM: GTP cyclohydrolase I; KEGG: pai:PAE0317 GTP cyclohydrolase I, conjectural.
  
  
 0.899
Pisl_1636
PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I.
  
 
 0.857
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.785
Pisl_0947
Molybdopterin synthase subunit MoaD; TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pai:PAE2135 hypothetical protein.
       0.688
cysS
KEGG: pai:PAE0821 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia.
  
  
 0.648
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
 0.622
Pisl_0945
SMART: iron-sulfur cluster loop; KEGG: pai:PAE2138 hypothetical protein.
       0.585
Pisl_0944
PFAM: protein of unknown function DUF711; KEGG: pai:PAE2151 hypothetical protein.
       0.574
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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