Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_0979Glucokinase; PFAM: ROK family protein; KEGG: pai:PAE3437 glucokinase (ROK family protein), conjectural. (315 aa)    
Predicted Functional Partners:
Pisl_1645
TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: sugar isomerase (SIS); KEGG: pai:PAE1610 hypothetical protein.
 
 
 0.960
Pisl_1718
PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH domain protein; KEGG: pai:PAE1761 myo-inositol-1-phosphate synthase.
     
 0.901
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.890
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
    
  0.812
Pisl_1776
PFAM: Transketolase domain protein; KEGG: pai:PAE1929 transketolase (N terminal section).
    
 0.808
Pisl_1775
Transketolase subunit B; PFAM: Transketolase, central region; Transketolase domain protein; KEGG: pai:PAE1927 transketolase (C terminal section).
    
  0.803
Pisl_1117
PFAM: PfkB domain protein; KEGG: pai:PAE0835 sugar kinase, possible phosphofructokinase; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.705
Pisl_1708
PFAM: glycoside hydrolase, family 1; KEGG: pai:PAE1736 beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.
 
  
 0.628
Pisl_0980
Glutamate dehydrogenase (NAD); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE3438 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.627
dapAL
PFAM: dihydrodipicolinate synthetase; KEGG: pai:PAE2915 dihydrodipicolinate synthase; Belongs to the DapA family.
 
  
 0.612
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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