Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
htpXHeat shock protein, Metallo peptidase, MEROPS family M48B; PFAM: peptidase M48, Ste24p; KEGG: pai:PAE3461 heat shock protein, htpX homolog, conjectural; Belongs to the peptidase M48B family. (347 aa)    
Predicted Functional Partners:
Pisl_1364
Pantothenate kinase; KEGG: pai:PAE3407 hypothetical protein.
  
    0.845
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.812
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate. Belongs to the LDH/MDH superfamily.
  
 0.744
Pisl_0297
PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE2901 hypothetical protein.
  
    0.694
Pisl_1034
Ala-tRNA(Pro) hydrolase; PFAM: Threonyl/alanyl tRNA synthetase, SAD; KEGG: pai:PAE2317 alanyl-tRNA synthetase related protein.
  
    0.655
Pisl_1692
KEGG: pai:PAE1689 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 
 0.642
Pisl_0991
Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: pai:PAE3465 molybdenum cofactor biosynthesis protein.
   
   0.583
Pisl_0649
Molybdopterin synthase subunit MoaD / molybdopterin synthase subunit MoaE; TIGRFAM: MoaD family protein; PFAM: molybdopterin biosynthesis MoaE; thiamineS protein; KEGG: pai:PAE0727 molybdenum cofactor biosynthesis protein D/E.
  
  
 0.581
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.576
Pisl_0625
ABC transporter related protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; ABC transporter related; Possible metal-binding region in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: pai:PAE2352 RNase L inhibitor homolog.
  
    0.573
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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