Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_1107PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: pai:PAE0820 mRNA 3'-end processing factor, conjectural. (640 aa)    
Predicted Functional Partners:
spt5
LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
 
 
 
 0.843
Pisl_1106
PFAM: pyruvate kinase; KEGG: pai:PAE0819 pyruvate kinase; Belongs to the pyruvate kinase family.
 
     0.818
Pisl_0922
DNA-directed RNA polymerase, subunit E; PFAM: RNA binding S1 domain protein; RNA polymerase Rpb7-like; KEGG: pai:PAE3562 DNA-directed RNA polymerase subunit E'.
  
 
   0.812
Pisl_0702
DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.785
Pisl_0703
DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.785
spt4
DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
  
 
 
 0.775
rpoD
DNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
    
 
 0.704
rpoL
DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
   
 
 0.703
rpoK
DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.
    
   0.697
rpoN
DNA-directed RNA polymerase, subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
    
   0.697
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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