Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_1114TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: pai:PAE0832 adenylate cyclase. (176 aa)    
Predicted Functional Partners:
Pisl_0088
PFAM: NUDIX hydrolase; KEGG: pai:PAE0252 diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (MutT/NUDIX family protein).
    
 0.902
Pisl_0673
PFAM: NUDIX hydrolase; KEGG: pai:PAE0714 diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (MutT/NUDIX family protein).
    
 0.902
Pisl_1626
PFAM: nucleoside diphosphate kinase; KEGG: pai:PAE1561 nucleoside diphosphate kinase.
    
  0.902
Pisl_0226
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: tko:TK2298 anaerobic ribonucleoside-triphosphate reductase.
     
  0.900
Pisl_0548
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
Pisl_1113
KEGG: pai:PAE0831 hypothetical protein.
       0.890
gch3
GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
  
  
  0.831
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.812
Pisl_1636
PFAM: GTP cyclohydrolase I; KEGG: pai:PAE1588 GTP cyclohydrolase I.
     
  0.800
Pisl_1112
PFAM: AMMECR1 domain protein; KEGG: pai:PAE0830 hypothetical protein.
 
     0.789
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.