Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_1202KEGG: pai:PAE1022 thiamine-monophosphate kinase part 2, authentic frameshift. (284 aa)    
Predicted Functional Partners:
Pisl_1419
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pai:PAE2535 phosphomethylpyrimidine kinase.
    
 0.951
Pisl_0356
KEGG: pai:PAE2951 hypothetical protein.
     
  0.900
Pisl_0548
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
adkA
KEGG: pai:PAE1681 adenylate kinase; Belongs to the archaeal adenylate kinase family.
     
  0.900
Pisl_1203
KEGG: pai:PAE1018 hypothetical protein.
       0.826
Pisl_1201
KEGG: pai:PAE1026 hypothetical protein.
       0.670
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
      
 0.613
Pisl_0386
PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; KEGG: pai:PAE2986 GTP cyclohydrolase II.
 
   
 0.590
Pisl_1204
PFAM: protein of unknown function UPF0047; KEGG: pai:PAE1017 hypothetical protein.
 
   
 0.572
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.569
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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