Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (269 aa)    
Predicted Functional Partners:
Pisl_1561
KEGG: pai:PAE1438 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.
 
  
 0.930
Pisl_0898
Cytidyltransferase-related domain protein; KEGG: pai:PAE2259 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase.
    
 0.920
Pisl_0737
PFAM: ATP-NAD/AcoX kinase; KEGG: pai:PAE0624 NAD+ kinase.
    
 0.919
Pisl_1971
ATP-NAD/AcoX kinase; PFAM: regulatory protein, ArsR; ATP-NAD/AcoX kinase; KEGG: pai:PAE3116 hypothetical protein.
    
 0.919
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
    
 0.918
cobB-2
PFAM: Silent information regulator protein Sir2; KEGG: pai:PAE3500 NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily.
    
 0.918
nadE-2
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 
0.903
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.848
Pisl_1303
PFAM: transcriptional regulator PadR family protein; KEGG: pai:PAE1218 hypothetical protein.
       0.789
Pisl_0389
PFAM: Quinolinate phosphoribosyl transferase; KEGG: pai:PAE2990 nicotinate phosphoribosyltransferase.
 
  
 0.605
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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