Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Pisl_1685Archease family protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (147 aa)    
Predicted Functional Partners:
rtcB
PFAM: protein of unknown function UPF0027; KEGG: pai:PAE0998 hypothetical protein; Belongs to the RtcB family.
 
 0.988
Pisl_1684
PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pai:PAE1677 hypothetical protein.
       0.789
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.772
rtcA
RNA-3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
 
 
 0.674
adkA
KEGG: pai:PAE1681 adenylate kinase; Belongs to the archaeal adenylate kinase family.
       0.602
Pisl_1686
3-hexulose-6-phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: pai:PAE1679 D-arabino 3-hexulose 6-phosphate formaldehyde lyase, conjectural.
       0.584
Pisl_1688
KEGG: pai:PAE1683 hypothetical protein.
       0.522
egsA
3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
       0.522
Pisl_0665
PFAM: Fmu (Sun) domain protein; PUA domain containing protein; KEGG: pai:PAE0743 RNA binding protein (fmu, PcnA P120 homolog), probable.
     
 0.406
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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