STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_1816PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE3438 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (421 aa)    
Predicted Functional Partners:
Pisl_0400
Sulfide dehydrogenase (flavoprotein) subunit SudA; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: pai:PAE3227 glutamate synthase small subunit.
  
 0.956
Pisl_1672
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pai:PAE1651 isocitrate dehydrogenase.
   
 0.948
Pisl_0144
PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp; KEGG: pai:PAE2556 glutamine synthetase.
  
 
 0.926
Pisl_0770
PFAM: aminotransferase, class I and II; KEGG: pai:PAE2251 aspartate aminotransferase (aspC), conjectural.
  
 
 0.924
Pisl_1791
L-aspartate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: pai:PAE1964 aspartate aminotransferase, conjectural.
  
 
 0.919
Pisl_1620
Carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: pai:PAE1552 carbamate kinase; Belongs to the carbamate kinase family.
     
 0.915
purQ
Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
    
  0.908
Pisl_1692
KEGG: pai:PAE1689 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 0.905
Pisl_0980
Glutamate dehydrogenase (NAD); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE3438 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 
0.900
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate. Belongs to the LDH/MDH superfamily.
  
 
 0.864
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.