Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_1965Dihydroorotase; PFAM: amidohydrolase; KEGG: pai:PAE0322 dihydroorotase (pyrC). (378 aa)    
Predicted Functional Partners:
pyrB
KEGG: pai:PAE0770 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.
 0.999
Pisl_0507
PFAM: dihydroorotate dehydrogenase; KEGG: pai:PAE3263 dihydroorotate dehydrogenase.
 
 0.997
carA
TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: pai:PAE0946 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family.
  
 0.994
carB
TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: pai:PAE0947 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.
 
 0.994
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.973
pyrI
Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
 
  
 0.967
Pisl_1063
TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: pai:PAE0768 orotidine-5'-monophosphate decarboxylase.
  
  
 0.964
Pisl_1966
SMART: AAA ATPase; KEGG: pai:PAE0320 P.aerophilum family 417, putative ATP binding.
       0.789
Pisl_1967
PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: pai:PAE0318 hypothetical protein.
  
  
 0.773
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
   
 0.738
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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