Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Pisl_1971ATP-NAD/AcoX kinase; PFAM: regulatory protein, ArsR; ATP-NAD/AcoX kinase; KEGG: pai:PAE3116 hypothetical protein. (293 aa)    
Predicted Functional Partners:
Pisl_0737
PFAM: ATP-NAD/AcoX kinase; KEGG: pai:PAE0624 NAD+ kinase.
  
  
  0.968
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.919
nadE-2
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.919
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
  
 
 0.918
cobB-2
PFAM: Silent information regulator protein Sir2; KEGG: pai:PAE3500 NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.918
Pisl_0898
Cytidyltransferase-related domain protein; KEGG: pai:PAE2259 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase.
    
 0.913
Pisl_1561
KEGG: pai:PAE1438 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.
    
 0.913
Pisl_1970
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pai:PAE0315 ABC-2 type transport system ATP-binding protein.
  
   0.695
Pisl_0665
PFAM: Fmu (Sun) domain protein; PUA domain containing protein; KEGG: pai:PAE0743 RNA binding protein (fmu, PcnA P120 homolog), probable.
  
    0.665
Pisl_1969
PFAM: ABC-2 type transporter; KEGG: pai:PAE0316 ABC-2 type transport system, membrane protein.
       0.659
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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