STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_1995Formate dehydrogenase beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE2661 formate dehydrogenase beta subunit. (278 aa)    
Predicted Functional Partners:
Pisl_1994
Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2662 formate dehydrogenase alpha subunit.
 
 0.996
Pisl_1996
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
    
  0.969
Pisl_1987
KEGG: hdu:HD1111 formate dehydrogenase, gamma subunit.
    
  0.952
Pisl_1988
PFAM: molydopterin dinucleotide-binding region; KEGG: tdn:Tmden_0500 twin-arginine translocation pathway signal.
 
 
 0.923
Pisl_0219
PFAM: formylmethanofuran dehydrogenase, subunit E region; KEGG: pab:PAB0675 molybdenum formylmethanofuran dehydrogenase subunit fmdE related.
 
  
  0.914
Pisl_0160
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
    
  0.910
Pisl_0266
PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2840 molybdopterin oxidoreductase, molybdopterin binding subunit part 1, authentic frameshift.
 
 
 0.904
Pisl_0162
PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2859 molybdopterin oxidoreductase, molybdopterin binding subunit.
 
 0.880
Pisl_1997
KEGG: pai:PAE2659 formate dehydrogenase protein fdhE.
  
  
 0.828
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate. Belongs to the LDH/MDH superfamily.
    
 0.817
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.