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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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thi4Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (273 aa)    
Predicted Functional Partners:
Pisl_1419
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pai:PAE2535 phosphomethylpyrimidine kinase.
  
  
 0.908
Pisl_1999
KEGG: pai:PAE0173 ribosomal protein L24, conjectural.
       0.890
Pisl_1450
Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: pai:PAE0333 thiamine biosynthesis protein.
  
  
 0.835
rps27ae
PFAM: Ribosomal protein S27a; KEGG: pai:PAE2432 ribosomal protein S27; Belongs to the eukaryotic ribosomal protein eS31 family.
       0.556
rps24e
PFAM: Ribosomal protein S24e; KEGG: pai:PAE2434 ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.
       0.556
Pisl_1996
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
       0.553
Pisl_1997
KEGG: pai:PAE2659 formate dehydrogenase protein fdhE.
       0.553
Pisl_0615
dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.552
Pisl_0825
Mn2+-dependent serine/threonine protein kinase; PFAM: protein of unknown function RIO1; KEGG: pai:PAE2192 hypothetical protein.
       0.552
kae1
Putative metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family.
       0.552
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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