STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thi4Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (273 aa)    
Predicted Functional Partners:
Pisl_1419
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pai:PAE2535 phosphomethylpyrimidine kinase.
  
  
 0.891
Pisl_1999
KEGG: pai:PAE0173 ribosomal protein L24, conjectural.
       0.829
Pisl_1450
Hydroxymethylpyrimidine synthase; PFAM: thiamine biosynthesis protein ThiC; KEGG: pai:PAE0333 thiamine biosynthesis protein.
  
  
 0.760
Pisl_1996
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
       0.553
Pisl_1997
KEGG: pai:PAE2659 formate dehydrogenase protein fdhE.
       0.553
Pisl_1995
Formate dehydrogenase beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE2661 formate dehydrogenase beta subunit.
       0.491
Pisl_1994
Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2662 formate dehydrogenase alpha subunit.
       0.489
Pisl_1993
Hypothetical protein.
       0.486
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.