Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_2000PFAM: amidohydrolase; KEGG: pai:PAE0309 chlorohydrolase, conjectural. (351 aa)    
Predicted Functional Partners:
gch3
GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
 
     0.783
Pisl_1833
TIGRFAM: riboflavin synthase; KEGG: pai:PAE2021 riboflavin synthase beta chain.
 
     0.693
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
    0.646
Pisl_0386
PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; KEGG: pai:PAE2986 GTP cyclohydrolase II.
 
     0.629
Pisl_0934
SMART: helicase c2; KEGG: pai:PAE3526 hypothetical protein.
 
    0.581
Pisl_0535
PFAM: CBS domain containing protein; KEGG: pai:PAE3169 conserved protein with 7 CBS domains.
 
    0.571
Pisl_1851
KEGG: pai:PAE2059 hypothetical protein.
 
     0.561
Pisl_2001
Transcriptional regulator, ArsR family; PFAM: regulatory protein, ArsR; KEGG: pai:PAE0303 hypothetical protein.
       0.551
Pisl_1612
PFAM: FAD dependent oxidoreductase; KEGG: pai:PAE1543 hypothetical protein.
 
  
 0.549
Pisl_1688
KEGG: pai:PAE1683 hypothetical protein.
 
  
 0.542
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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